We Need to Stop Drug-Resistant Malaria at Its Source, Right Now
Considerable investments have averted millions of malaria-attributable deaths since 2000. Nevertheless, one person (usually a child) still dies every 1.2 minutes from this disease. There was no reduction in mortality overall between 2015 and 2016, and mortality actually increased in some regions. In the most recent World Malaria Report, 219 million cases were reported in 2017, an increase of two million.
Malarial drug inhibits Zika virus growth, IIT Mandi team finds
Researchers at Indian Institute of Technology (IIT) Mandi have found a drug hydroxychloroquine or HCQ, that is already being used for treating malaria to be effective in inhibiting Zika virus growth and replication. Since the HCQ drug is already approved for use in pregnancy, positive results in human trials will mean that it can be given to pregnant women infected with Zika to reduce the chances of vertical transmission.
FFAR Launches International Consortium for Antimicrobial Stewardship in Agriculture
The Foundation for Food and Agriculture Research (FFAR) today launched the International Consortium for Antimicrobial Stewardship in Agriculture (ICASA), a public-private partnership to advance research on antimicrobial stewardship in animal agriculture and improve animal health and welfare. Antibiotics are extremely valuable tools in the effort to protect animal health. Maintaining the efficacy of antibiotics is a highly complex issue, affecting both human and animal health, and it is a top priority for veterinarians and livestock producers.
Takeda dengue vaccine meets main goal of trial; detailed results to come
Takeda Pharmaceutical Co said on Tuesday that its experimental dengue vaccine appears to be safe and effective at preventing all four types of the mosquito-borne disease, meeting the main goal of the Japanese drugmaker’s late-stage clinical trial. Takeda said it will release full details of how the vaccine fared at 15 months after the first dose in a peer-reviewed journal as quickly as possible.
Effect of Adding Azithromycin to Seasonal Malaria Chemoprevention
Daniel Chandramohan et al.,
We randomly assigned children 3 to 59 months of age, according to household, to receive either azithromycin or placebo, together with sulfadoxine–pyrimethamine plus amodiaquine, during the annual malaria-transmission season in Burkina Faso and Mali. The drug combinations were administered in four 3-day cycles, at monthly intervals, for three successive seasons.
MMV and DNDi make 400 compounds available to stimulate research into new drugs for pandemic diseases
Medicines for Malaria Venture (MMV) and the Drugs for Neglected Diseases initiative (DNDi) have launched the Pandemic Response Box to provide researchers with free access to 400 diverse compounds to accelerate the discovery of new treatments for life-threatening pandemic diseases. The Pandemic Response Box is a collection of structurally diverse antibacterial, antiviral and antifungal compounds – selected by disease experts – for screening against infective and neglected diseases.
Understanding drivers of antibiotic resistance genes in High Arctic soil ecosystems
An international team of scientists reported yesterday that they have detected antibiotic resistance genes in soil from remote group of islands the High Arctic, a finding they say illustrates the global nature of the threat. Among the genes found by the team was blaNDM-1 (New Delhi metallo beta-lactamase-1), which confers resistance to a broad range of antibiotics and has been associated with highly resistant bacterial pathogens and severe, multidrug-resistant infections.
Jakarta on dengue alert as outbreak spreads in Indonesia
Jakarta is on alert as cases of dengue fever have surged in recent weeks, claiming more than 100 lives across Indonesia since the start of the year. The authorities said the dengue outbreak is due to the rainy season, and that efforts will be made to ramp up vector control, or mosquito eradication, by fogging, covering drains and other methods to stave off mosquito breeding.
Improving emergency preparedness and response in the Asia-Pacific
Ben J Marais et al.,
Given that the Asia-Pacific region is a recognised hotspot for disease emergence and spread, every effort should be made to improve regional health security by strengthening and advancing adequate disease surveillance and response capacity. In general, efforts within and collaboration between the Western Pacific and South-East Asia regions have been exemplary, but many challenges remain.
Draft recommendations of the Ad hoc Interagency Coordination Group on Antimicrobial Resistance
An ad hoc expert panel convened by the UN secretary-general in March 2017 yesterday published guidelines on antimicrobial resistance (AMR) and is seeking public input, the World Health Organization (WHO) announced. The Interagency Coordination Group (IACG) on Antimicrobial Resistance has a mandate "to provide practical guidance for approaches needed to ensure sustained effective global action to address antimicrobial resistance," the WHO said.
The deadline for submitting feedback is Feb 19, and an email address is provided in the WHO announcement.